What Makes Us Human: Cooperation, Knowledge, and the Will to Survive

In the vast story of life on Earth, humans are primates—but not just any primates. We don’t outmatch our cousins in strength, speed, or sharp claws. What sets us apart is something subtler and far more powerful: the ability to learn from one another, to share knowledge, and to cooperate. That’s what has allowed us to inhabit virtually every environment on the planet—from sun-scorched deserts to icy tundra, from megacities to rainforests.

I was reminded of this truth in the most unexpected place: traveling to Southwestern Uganda and standing mere feet from a 400-pound silverback gorilla in Bwindi Impenetrable Forest. His species split from our evolutionary lineage roughly eight million years ago. The mountain gorillas have remained in the forest, perfectly suited to a single ecological niche. We, by contrast, left the trees behind—and never stopped moving.

But what enabled that journey wasn’t just intelligence. Intelligence without connection doesn’t scale. The secret to our success is shared wisdom.

History offers a cautionary tale. In 1861, the British explorers Burke and Wills attempted to cross the Australian continent from south to north. They dismissed the hard-won survival knowledge of Aboriginal Australians, particularly around the preparation of nardoo seeds. Eaten raw, nardoo contains thiaminase, an enzyme that destroys vitamin B1. The explorers suffered and died of beri-beri—not because survival knowledge was unavailable, but because they refused to accept it. Ignorance wasn’t fatal—arrogance was.

Now contrast that with our modern trek through East Africa—an exercise in cooperative survival:

Medicine as shared defense: Vaccinations against yellow fever, permethrin-treated clothes, Malarone tablets, and a discreet cache of Imodium. All forged through centuries of global collaboration in labs and clinics.

Engineering on four wheels: Our Toyota Land Cruisers tackled cratered dirt roads like lunar rovers. A tribute to mechanical ingenuity, tire durability, and suspension systems that earned their pay.

Linguistic diplomacy: Our guide—part biologist, part gorilla whisperer—spoke in deep, rumbling grunts to soothe a nearby silverback. When you’re five feet from a primate that could turn you into a protein shake, fluency in Silverbackese is a highly valued skill.

Microbial truce via refrigeration: Cold milk, safe cheese, and preserved fruit—unsung heroes in the war against gastrointestinal mutiny.

Batwa porters, forest-born navigators: Descendants of Bwindi’s original inhabitants, the Batwa led us with quiet confidence. They knew every slippery root, every hidden turn, every slope disguised as flat ground. Without them, we might still be in the forest, tangled in vines and excuses.

Security with edge: Kalashnikovs swung from the shoulders of armed guards like grim fashion statements. Their presence reminded us that peace, here, is maintained—not assumed. Just across the border lies Congo, and with it, a long shadow of past conflict. In Bwindi, tranquility often travels with a trigger finger.

The mountain gorillas remain tied to one patch of Earth, thriving in their ancient rhythm. We humans ventured far because we learned to listen—to guides, to science, to experience, and sometimes, finally, to each other.

We are primates. But we are the cooperative primates. The ones who teach, imitate, argue, share, and adapt.

And that—more than any tool or gene—has made us human.

It Could Be Worse

We live in difficult times. You feel it in the news cycle, in conversations with friends, even in the checkout line at the grocery store. The global fabric seems frayed: rising authoritarianism threatens democracies near and far. Tariffs destabilize markets. Inflation pinches wallets. And tensions in the Middle East raise the chilling specter of yet another devastating war.

And yet… it could be worse.

I had that thought—unironically—as I was hiking Park City Mountain this week. There, perched along the trail, was a volcanic basalt boulder. Not just any rock, but a time traveler from the Tertiary Period, roughly 40 million years ago. It had ridden a wave of molten fury from the earth’s crust in an eruption that once transformed the land we now ski, hike, and bike upon. It was a reminder that while human conflict and economic angst feel overwhelming, we are lucky to be living in the eye of Earth’s geological storm.

Consider Yellowstone—now a serene wonderland of geysers and elk—yet it harbors a supervolcano that exploded catastrophically during the same epoch. Its granitic fury could, if awakened again, obliterate the continent as we know it, sending Homo sapiens the way of the trilobite. It’s not hyperbole; it’s just Earth being Earth.

Add to that the glaciations that have repeatedly frozen much of the planet and the orogenic (mountain-building) periods that reshaped entire continents. And somehow, between ice sheets and magma floods, we humans managed to rise, build cities, write symphonies, and invent espresso machines. We’re living in a surprisingly stable window between cataclysms.

So I stood there next to that black basalt relic and whispered a small, slightly ironic prayer: Kiss the ground.

Because despite man’s inhumanity to man—despite corruption, division, and our perilous flirtation with extinction—we’re still here. And we still have choices. To treat each other better. To protect what’s left. To prepare wisely. To hold fast to the fragile but precious peace between geological and geopolitical upheavals.

We owe it to those who come next. And to those rocks that remind us:

It really could be worse.

Fritz Haber: The Scientist who Fed Millions and Fueled Wars

Life is riddled with paradoxes and ironies, a maze of contradictions where triumphs often come hand in hand with tragedy, and progress casts shadows as it illuminates the way forward. It is rarely a straight path; instead, it winds unpredictably through moments of creation and destruction, selflessness and ambition, brilliance and unintended consequence. Few figures embody this complexity more profoundly than Fritz Haber, a man whose scientific genius reshaped the world in ways both profound and catastrophic.

Fritz Haber: A Legacy of Creation and Destruction

Fritz Haber, a name etched into the annals of science and history, is both celebrated and condemned. Known as the “Father of Chemical Warfare”, his legacy is marked by groundbreaking advancements in chemistry that revolutionized agriculture and warfare. Haber’s work embodies the dual-edged nature of scientific progress—capable of sustaining life and facilitating destruction.

The Haber-Bosch Process: Feeding the World

At the turn of the 20th century, the world faced a dire challenge: the need for more food to sustain a rapidly growing population. Agriculture depended on natural sources of nitrogen, primarily derived from guano and nitrates mined in South America. These sources were finite and insufficient to meet global demand.

In 1909, Haber developed a process to synthesize ammonia from atmospheric nitrogen and hydrogen under high pressure and temperature, using an iron catalyst. This method, refined and industrialized by Carl Bosch, became known as the Haber-Bosch process. Ammonia synthesized through this process could be used to produce artificial fertilizers, dramatically increasing agricultural yields.

The Haber-Bosch process is credited with enabling the “Green Revolution,” feeding billions and fueling population growth. Today, nearly half of the world’s population depends on food grown with nitrogen fertilizers derived from this method.

Nitrates and the Prolonging of World War I

Haber’s discovery also had a darker application. During World War I, Germany was cut off from natural nitrate supplies used in explosives due to a British naval embargo. Haber’s process not only ensured Germany’s food production but also allowed the synthesis of nitrates for military use. His work bolstered the German war effort, prolonging the conflict despite material shortages.

The irony of Haber’s legacy is stark: the same chemical process that feeds billions also enabled the production of explosives that killed millions.

Chemical Warfare: The Birth of Modern Atrocities

Haber’s contributions to warfare did not end with nitrates. In 1915, he supervised the first large-scale deployment of chlorine gas at the Battle of Ypres, marking the dawn of modern chemical warfare. Chlorine gas, heavier than air, seeped into trenches, causing horrific injuries and deaths. Over 1,000 Allied soldiers perished in that single attack, and thousands more were incapacitated.

Haber viewed chemical warfare as a necessary evolution of military strategy. He famously stated:

“During peace time, a scientist belongs to the world, but during war time, he belongs to his country.”

This philosophy drove his later work on chemical weapons, including the synthesis of cyanide gas, a precursor to the Zyklon B used by Nazi Germany in World War II to murder over a million people, including Jews in concentration camps.

A Nobel Prize Amidst Controversy

In 1918, Haber was awarded the Nobel Prize in Chemistry for his work on ammonia synthesis, despite widespread criticism for his role in chemical warfare. The award underscored the dual-use nature of scientific discoveries—how innovations can be lauded for their utility while being condemned for their consequences.

Persecution and Exile

Despite his service to Germany, Haber’s life took a tragic turn with the rise of the Nazi regime. Born into a Jewish family, Haber had converted to Lutheranism to integrate into German society. Yet his Jewish heritage made him a target under Hitler’s Third Reich.

Haber was forced to flee Germany in 1933. His family suffered greatly during the Holocaust; several relatives, including extended family, perished in concentration camps. This bitter irony—having contributed to Germany’s military might only to be rejected and persecuted—haunts Haber’s legacy.

Haber died in 1934, an exile from the country he once served so faithfully.

A Complex Legacy

Fritz Haber’s life is a testament to the profound impact of science on human civilization. His innovations in nitrogen fixation have fed billions, while his contributions to chemical warfare have caused untold suffering. Haber embodies the paradox of progress—how knowledge can be wielded for both creation and destruction.

Ultimately, his story is one of ambition, moral complexity, and the inescapable consequences of one’s actions, set against the backdrop of a turbulent century. His legacy challenges us to consider the ethical responsibilities that come with scientific discovery and the enduring impact of our choices.

 From Venom to Vitality—The Remarkable Story of GLP-1 Agonists 

Medical breakthroughs often emerge from unexpected sources, but few are as extraordinary as the discovery of GLP-1 agonists, compounds derived from the venom of the Gila monster. These molecules have revolutionized the treatment of diabetes and obesity, offering patients life-changing therapies like semaglutide and tirzepatide. With 75% of adults and 50% of teens classified as overweight or obese, these medications hold significant potential to impact public health outcomes.

As a gastroenterologist, I’m profoundly inspired by the journey that led to this discovery. It’s a story of curiosity, collaboration, and the transformative power of nature. It also underscores the critical importance of exploring venomous species for medical research and utilizing advanced techniques like chromatography to uncover therapeutic compounds.  

The Gila Monster: A Surprising Source of Healing  

Native to the deserts of the American Southwest, the Gila monster is a slow-moving, venomous lizard known for its tenacious bite. While its venom evolved as a defense mechanism, scientists saw potential beyond its lethality. The venom contains exendin-4, a compound remarkably similar to GLP-1, a gut hormone that regulates blood sugar and appetite.  

GLP-1 plays a central role in metabolism, signaling the pancreas to release insulin and the brain to reduce hunger. This discovery was a turning point. By isolating and modifying the Gila monster’s exendin-4, researchers created the first GLP-1 receptor agonist, exenatide, paving the way for more advanced therapies like semaglutide and tirzepatide.  

Chromatography: Unlocking Nature’s Secrets  

The breakthrough required cutting-edge technology and meticulous research. Chromatography, a technique used to separate complex mixtures, was instrumental in analyzing the venom. Despite working with minuscule samples, scientists isolated and identified exendin-4 among a multitude of bioactive compounds.  

This success highlights the power of chromatography in venom research, enabling scientists to uncover molecules with potential therapeutic benefits. It also demonstrates how even the smallest discoveries in nature can lead to monumental advances in medicine.  

Collaboration: The Key to Progress  

The discovery of GLP-1 agonists was a collaborative effort, bringing together experts in endocrinology, pharmacology, and gastroenterology. The interdisciplinary approach allowed the team to connect the dots between a venomous lizard and the human gut’s metabolic pathways.  

This kind of collaboration is essential for modern medical research. By combining knowledge from diverse fields, we can tackle complex problems and open new frontiers in treatment.  

The Value of Venom in Medicine  

Venomous species, from snakes to scorpions to marine snails, are increasingly recognized as treasure troves of medicinal compounds. Their venoms contain molecules finely tuned by evolution to target specific biological pathways—making them ideal candidates for drug development.  

The Gila monster’s role in modern medicine is a testament to the untapped potential of venomous species. It reinforces the need to protect biodiversity and invest in research that explores the medical applications of venom.

A Florida Perspective

As a retired gastroenterologist in Florida, I now spend more time dodging iguanas and geckos on the golf course than in the lab. Still, the allure of discovery lingers. I sometimes joke that I should stash an Erlenmeyer flask and a portable liquid chromatograph in my golf bag—just in case I stumble upon the next venomous breakthrough mid-round. Who knows? A particularly curious reptile encounter might even inspire an NIH grant application. Florida’s ecosystem is a constant reminder of the untapped potential in the natural world, from the fairways to the mangroves.

Conclusion  

The story of GLP-1 agonists is more than a medical milestone—it’s a reminder of the importance of curiosity and collaboration. It challenges us to look beyond the surface and explore the natural world with an open mind, knowing that the next breakthrough could come from the most unlikely source.  

By harnessing the power of venom and embracing the wonders of nature, we’re not just advancing medicine; we’re honoring the interconnectedness of life itself. And as a gastroenterologist, I’m proud to celebrate the scientific ingenuity that transformed a venomous lizard into a symbol of hope and healing.  

Hope for My Grandson’s Future

The alarm blared at 6:00 AM wakening me from a deep slumber. An early message in retirement is never a good thing, I thought, as I brought up the message icon. Our ‘grandson to be’ had decided to arrive five weeks early. We booked our airline flights to the nation’s capitol and arrived, rumpled and tumbled by the Uber drive over the Potomac, to our hotel off the National Mall.

Too much knowledge can be a dangerous thing, we pondered, as grandparents with 70 lifetime years of pediatric and internal medicine experiences. Lung function, oxygen requirements, surfactant, feeding ability, brain development and infection risk percolated through our collective anxiety. Scientific probability tempered with prayer was the way to dispel these troubling thoughts.

He was born fully formed, loudly screaming and feisty. He entered the Neonatal ICU for warmth, feeding, oxygen and observation time for the next 10 days as we wandered around Washington, D.C. awaiting his discharge and arrival to his parents’ home.

My  anxiety was heightened by the present and past of the U.S.A.  A man with a train conductor’s hat sat in front of the White House blaring music and chanting, “We are on the train of destruction.” Placards in front of the Capitol declared the illegality of vaccination for union workers. We strolled to our grandson’s future home by passing the Garfield Statue (assassinated president) and Ulysses S. Grant on Horseback (Civil War with 600,000 dead). We continued on past well dressed legislative assistants (struggling to pass much needed infrastructure bills) coming out of the Richard Russell Building.  I looked up Richard Russell, who was a former Senator from Georgia who defended Jim Crow and obstructed Civil Rights legislation, and wondered how his name was chosen for an entire building in Washington DC. 

Our grandson was thriving, gaining weight and bonding with his parents. Relieved, we passed the time in our nation’s collective warehouse: the Smithsonian Institution. Endowed by James Smithson, a wealthy Englishman who dabbled in chemistry and mineralogy in 1820, who generously donated his inheritance to a country he never set foot in for the cause to advance science and knowledge.  The Wright Brothers started their research through the museum’s scientific holdings and solved the heavier than air flight conundrum that baffled the world’s best minds. Lieutenant Commander Philip Van Horn Weems, recruited by Charles Lindbergh to perfect a better aviation navigational system led to an era of safer air travel for all. We saw the art of Saul Bellows documenting urban life in the early 20th century and appreciated the genius of the early neoclassical architects such as James Renwick, Charles Bullfinch and William Thornton who shaped our Capitol and early federal buildings.

At the Library of Congress we saw a portion of the over 800 miles of library stacks and more than 25,000,000 volumes that are available to all Americans that wish to research any topic and can participate in a plethora of summer programs for kids to introduce them to learning and research. This spectacularly beautiful building was full of historical treasures and important information. For example, we learned of the accountability of a democracy, embodied by the Presidential Recovery Act of 1978 that transfers Presidential papers to the public domain after office. This Federal Act was prompted by the willful burning of presidential records by Grover Cleveland, Millard Fillmore and numerous other Commanders-in-Chief.  

Throughout our stay in DC we continued our US historical scavenger hunt: we saw the documents of Lincoln establishing agricultural/land grant colleges in the 19th century that created American engineering superiority, the bravery of Harriet Tubman guiding slaves to their freedom through the Underground Railroad and the bigger than life statue of Albert Einstein in front of the National Science Administration accompanied by his proclamation of free thought in his new country and safe harbor away from fascism.

Opportunity, American ingenuity, hard work and the limitless resources of art, science, politics and jurisprudence documented in our nation’s capitol left us truly humbled. The presence of such endless possibility that is freely bestowed upon every American Citizen— in the backdrop of our grandson’s birth— left us in awe and rendered us speechless.

 Our grandson graduated from the Neonatal ICU into his home now several ounces heavier, with healthy lungs and an animated disposition. We, as grandparents, are now in the grandstand joyfully watching every moment of his wonderful life. Just knowing that opportunity and choice are around the corner as he grows and prospers in our great country brings us comfort as US citizens and hope for a brighter future for our newest patriot and family member.